Further information on drug naming conventions: International Nonproprietary Names. Important Allerhy The Drugs. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you.
Although far from ideal, this method can allow the causative agent to be distinguished: whether this is human insulin, or an excipient. A copy of the allsrgy consent is available for review by the Editor-in-Chief of this journal.
BW conceived and wrote the manuscript, as well as managed the patient from diagnosis through to treatment. BT was a major contributor in writing allergy manuscript, and assisted in the diagnostic process and its conception. All authors read and approved the final manuscript. The authors wish to thank Cresol. Robert Mac Gardiner for his help with editing the manuscript and also the patient and her family for their forbearance during the diagnostic and treatment process and for their permission to publish this manuscript.
National Center for Biotechnology InformationU. J Med Case Rep. Published online Aug Author information Article notes Copyright and License information Disclaimer.
m-Cresol | CH3C6H4OH - PubChem
Corresponding author. Benjamin J Wheeler: zn. Received Mar 9; Accepted Jul 5. This article has been cited by other articles in PMC.
Case presentation We present the case of a year-old Caucasian girl with localized allergy to the insulin excipient metacresol, and the subsequent desensitization therapy using continuous subcutaneous insulin infusion with allegry intravenous allergy infusion. Conclusions This is the first documented case of allergy to the metacresol component of insulin in the pediatric type 1 diabetes literature. Introduction Insulin allergy, although less common since the introduction of cresol insulin [ 1 ], is still an issue in the management of diabetes.
Open in allery separate window. Figure 1.
Cresol - Wikipedia
Figure 2. Discussion We describe the first documented case of an allergic reaction to the metacresol component of insulin in the pediatric T1DM aloergy. Conclusions In this report we document the first case of allergy to metacresol in the pediatric diabetes literature; metacresol is an excipient common to all currently available insulin preparations.
Competing interests The authors declare that they have no competing interests. Acknowledgements The authors wish to thank Prof. References Schernthaner G. Immunogenicity and allergenic potential of animal and human insulins. Diabetes Care. Insulin allergy: background, diagnosis and treatment. Ned Tijdschr Geneeskd. Allergy reactions to insulin: effects of continuous subcutaneous insulin infusion and insulin analogues.
Diabetes Metab Res Rev. Severe anaphylactic reaction to human insulin in a diabetic patient.
Toxicity of insulin due to phenol and metacresol | Diabetes Forum • The Global Diabetes Community
J Diabetes Complications. Insulin allergy: clinical manifestations and management strategies. Immediate-type human insulin allergy successfully treated by continuous subcutaneous insulin infusion.Chlorocresol (p-chloro-m-cresol) is a biocide used as a disinfectant and preservative in a wide range of products. It is currently found in a 1% concentration in petrolatum in cosmetics, hairdressing products, preservatives, prod-ucts for treating skin ulcers, and cutting ﬂuids. It is even in the standard series of some groups, such as the British. Delayed-type hypersensitivity reaction to the meta-cresol component of insulin. each with a different time of onset and duration of action. 3 The full gamut of IgE-mediated immediate-type allergy, phenol, dibasic sodium phosphate, and zinc. Reactions to o-cresol and phenol have been reported but none to m-cresol Cited by: Feb 29, · For example, Novorapid contains mg/ml of phenol and mg/ml of metacresol. Both of these substances are very toxic, and for someone who is injecting 20 units of insulin per day, means also ppm of phenol per day and ppm of m-cresol. Here is the study that was dealing with cell death induced with these substances.
Intern Med. A rational clinical approach allergy suspected insulin allergy: status after five years and 22 cases.
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It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.
Cresol consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices. Subscribe to Drugs. The name cresol reflects their structure, being alldrgy, and their traditional source, creosote. In its chemical structurea molecule of cresol has a methyl group substituted onto the ring of phenol.
Metacresol - xbsw.lion-wolf.ru
There are three forms isomers of cresol: ortho -cresol o -cresolmeta -cresol m -cresoland para -cresol crwsol -cresol. These forms occur separately or as a mixture, which can also be called cresol or more specifically, tricresol. Cresols are precursors or synthetic intermediates to other compounds and materials, including plastics, pesticides, pharmaceuticals, and dyes.
Most recently, cresols have beento create a breakthrough in manufacturing carbon nanotubes at scale that are separated and not twisted, without additional chemicals that change the surface properties of the nanotubes according to sciencedaily.
When cresols are inhaled, ingested, or applied to the skinthey can be very harmful. Effects observed in people include irritation and burning of skin, eyesmouthand throat ; abdominal crssol and vomiting; heart damage; anemia ; liver and kidney damage; facial paralysis; coma ; and death.Chlorocresol (p-chloro-m-cresol) is a biocide used as a disinfectant and preservative in a wide range of products. It is currently found in a 1% concentration in petrolatum in cosmetics, hairdressing products, preservatives, prod-ucts for treating skin ulcers, and cutting ﬂuids. It is even in the standard series of some groups, such as the British. Aug 31, · Insulin allergy, although less common since the introduction of human insulin , is still an issue in the management of diabetes. Suggested rates of insulin allergy range from anaphylaxis or death .Cited by: 5. Cresol. They are a widely occurring natural and manufactured group of aromatic organic compounds, which are categorized as phenols (sometimes called phenolics). Depending on the temperature, cresols can be solid or liquid because they have melting points not far from room temperature. Like other types of .
Breathing high levels of cresols for a short time results in irritation of the nose and throat. Cresol from these effects, very little is known about the effects of breathing cresols, for example, at lower levels over longer times.
Ingesting high levels results in kidney problems, mouth and throat burns, abdominal pain, vomiting, and effects on the allergy and nervous system.