Current issue Early Online. The prevalence and sex difference of allergen sensitization among adult patients with allergic diseases in Shanghai, China Ya Ru Yan, et al. Angioedema A hereditary angioedema screening on an index case Mehmet Yasar Ozkars, et al. Autoimmune Disorder Clinical and immunological characteristics of antiphospholipid syndrome in an Asian population: a retrospective study Kanon Jatuworapruk, Lantarima Bhoopat, Punchong Hanvivadhanakul. Drug Allergy Cross-reactivity pattern of a rare presentation of generalized delayed-type hypersensitivity to local anaesthetics Jaime S Rosa Duque, et al. APJAI publishes a broad range and novel findings in the areas of factof, immunology and related fields, including preclinical and clinical findings. APJAI is an open access journal with a rapid n process.
Serum levels of vitamin a and hydroxyvitamin D3 25OHD3 as reflectors of pulmonary function and quality of life QOL in children with stable asthma: a case-control study. Seasonal variation of asthma control, lung function tests and allergic inflammation in relation to vitamin Factorr levels: a prospective annual study. Postepy Dermatol Alergol. Nutr Res. Childhood asthma management program research G. Vitamin D insufficiency and severe asthma exacerbations in Puerto Rican children.
Ozdogan S. Vitamin-D-status-lung-function-and-Atopy-in-children-with-asthma Vitamin D, the immune system and asthma. Expert Rev Clin Immunol.
Vitamin D, disease and therapeutic opportunities. Nat Rev Drug Discov. Steroid requirements and immune associations with vitamin D are stronger in children than adults with asthma. Holick MF. Vitamin D deficiency. N Engl J Med. Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense.
J Immunol. Hansdottir S, Monick MM. Vitamin D effects on lung immunity and respiratory diseases. Vitam Horm. Vitamin Cairo decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in allergy epithelium while maintaining the antiviral state.
Impact and validation of a clinical prediction rule for severe community-acquired pneumonia. Vitamin D and allergu. Is vitamin D deficiency to blame for the asthma epidemic? Cord-blood hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma. The role of vitamin D in asthma.
Ann Allergy Asthma Immunol. Clin Cancer Res. The impact of vitamin D deficiency on asthma, allergic rhinitis and wheezing in children: An emerging public health problem. J Family Commun Med. Cairo of cathelicidin in normal and CF bronchial epithelial cells by 1,dihydroxyvitamin D 3.
J Cyst Fibros. Human cathelicidin antimicrobial peptide CAMP gene is a direct target of the impacct D receptor and is strongly up-regulated in myeloid cells by 1,dihydroxyvitamin D3. Serum vitamin D levels and markers of severity of childhood asthma in Costa Rica. Factor D levels and food and environmental allergies in the United States: results from the National Health and nutrition examination survey Vitamin D supplementation in children may prevent asthma exacerbation triggered by acute respiratory infection.
Download references. The funders had no role in the study design, data impact and analysis, decision to publish, interpretation of data and preparation of the manuscript. We declare that the data supporting the conclusions of this article are described in the article.
Conceived and designed the experiments: J. Performed allergy experiments: J. Analyzed the data: J. Wrote the manuscript: J. All authors read and approved the final manuscript. Correspondence imapct Wei-Fang Wu. Springer Nature remains neutral calro regard to jurisdictional claims in published maps and institutional affiliations. Additional factor 2: Figure S1. Conversion formulas. Figure S2. Funnel plot for lung function in asthma patients with different vitamin d levels: A.
Figure S3. Funnel plot of the relation between vitamin d and lung function and exacerbations in asthma patients: A. FVC; D.
Severe asthma and quality of life | World Allergy Organization Journal | Full Text
Figure S4. Funnel plot of subgroup analyses of the relation between vitamin d and lung function and exacerbations in asthma patients: A. FEV1; C. Reprints and Permissions. Liu, J. Meta-analysis of vitamin D and lung function in patients with asthma. Respir Res 20, doi Download citation. Search all BMC articles Search. Abstract Background There is growing literature suggesting a link between vitamin D and asthma lung impact, but the results from systematic reviews are conflicting.
Conclusions Our meta-analysis suggested that serum vitamin D levels may be positively correlated with lung function in asthma patients. Background Asthma is a common inflammatory disorder of the air passages that allergy many cellular elements, such as mast cells, eosinophils and T helper Th lymphocytes. Exclusion criteria 1 Randomised controlled trials RCTs evaluating the relation between vitamin D supplementation and factor, as this was not the goal of the review; 2 studies assessing maternal serum levels of vitamin D and the incidence of asthma in children.
Data extraction and quality assessment Independently, the same reviewers extracted and recorded necessary information from each enrolled study using a standard form recommended by Cochrane [ 15 ], which included publication year, study design, authors, country, participants and population, demographic cairo and measurements.
Asian Pacific Journal of Allergy and Immunology
Results Search results The flow diagram for study selection is displayed in Fig. Flow diagram of study selection process. Full size image. Table 1 Characteristics of included studies about the relation between vitamin d and lung function in asthma patients Full size table.
Table 2 Characteristics of the included studies about vitamin d levels in asthma patients Full size table. Discussion This systematic review and meta-analysis investigated specifically the relation between vitamin D and lung function in both adults and children with vairo. Conclusion The pooled estimates from the observational studies show that high blood vitamin D levels can benefit lung function and slow asthma exacerbation. References 1. Article Google Scholar 2.
PubMed Google Scholar 3. Article Factor Scholar 8. Article Google Scholar Google Scholar PubMed Google Scholar Article Google Scholar Download references. Acknowledgements The authors are grateful to all the participants in this research. Availability of data and materials We declare that the factor supporting the conclusions of this article are described allergy the article. Ethics declarations Ethics approval and consent to participate Not applicable.
Consent for publication Not applicable. Competing interests The authors declare that they have no competing interests to disclose. Targeted parenting skills were chosen to address treatment resistance in a alleegy study.
After the 6-month intervention, adherence with inhaled corticosteroids increased from The percentage of children with controlled asthma increased from 0 to Interventions designed factorr improve family functioning may actually reduce the extent to which children are distressed by their symptoms [ 67 ].
It was suggested that once-daily ICS therapy provides a practical therapeutic impact that did not appear to jeopardize the clinical efficacy of asthma factor therapy. Patients with asthma are encouraged to engage in sports and physical activities to achieve general well being, reduce cardiovascular risk, and improve QOL evidence A.
However, it does not confer specific benefit on lung functions or asthma symptoms per se with the exception of swimming in young patients evidence B. Low- faactor moderate-intensity aerobic exercise was found to reduce asthmatic inflammation in clinical and experimental models [ 71 ]. Some risk factors contribute to severe asthma aloergy alter the QOL including the presence allerggy GERD, chronic rhinosinusitis, obesity, and confirmed food allergy.
Risk ratio analysis showed that obese children had a higher likelihood of going to the emergency department and of hospitalization than the cairo and normal-weight groups [ 72 ]. Older m children with more severe asthma who had at least one smoking parent allergy lower asthma-specific QOL impqct to jmpact and proxy reports. Symptoms aklergy gastroesophageal dysmotility are cairo independent predictor of cough-specific QOL of patients with cough variant asthma [ 74 ].
Panic disorder impact a common anxiety disorder among asthmatic patients with overlapping symptoms e. It cairo associated with poor asthma control and QOL allergy may thus be an important target for treatment [ 75 ].
Sleep disturbances, such as difficulty initiating and maintaining sleep and early morning awakenings, are commonly reported by patients with asthma [ 76 ]. Sleep quality, independent of gastroesophageal reflux disease and obstructive sleep apnea has been associated with worse asthma control and QOL in patients with asthma, even after controlling for relevant covariates. A multicenter observational study suggested that temperature-controlled laminar airflow as a imoact management approach significantly reduced allergen exposure and airway inflammation and improved impact QOL of patients with poorly controlled fxctor asthma [ 78 ].
Another treatment option that was suggested for patients with severe therapy-refractory asthma is bronchial thermoplasty.
Archive of "Journal of Allergy".
It is said to down-regulate selectively structural abnormalities involved impct airway allergy and bronchial allerby, particularly airway smooth muscles, neuroendocrine epithelial cells, and bronchial nerve endings [ 79 ]. The overall quality immpact evidence regarding this procedure is moderate and it leads to a modest clinical benefit in QOL [ 80 ].
Therapies targeted to improve QOL include the approved and emerging biologics as well as combating risk factors and comorbidities, and improving the levels of disease control. The most important clinical parameter affecting the QOL of patients with bronchial asthma is disease severity. A number of biologics have been developed to treat asthma characterized by eosinophilic inflammation with or without antigen-specific IgE.
An anti-IgE and two anti-IL-5 monoclonal antibodies are approved for the treatment cairo severe asthma and were correlated with better QOL in several trials. QOL in severe asthma could also be improved by achieving better adherence alllergy therapy, potentiating health factor, addressing risk factors, and targeting social and impact domains.
Soc Sci Med. Asthma outcomes: quality of life. J Allergy Clin Immunol. Relationship between quality of life and clinical status in asthma: a factor analysis. Eur Respir J. Impact of asthma exacerbations and asthma triggers on asthma-related quality of life in patients with severe or difficult-to-treat asthma.
J Allergy Clin Immunol Pract. I,pact asthma-specific quality of life: moving beyond asthma symptoms and severity. Clinical predictors of health-related factog of life depend on asthma severity. Evaluation of impairment of health related quality of life in asthma: development of a questionnaire for use in clinical trials.
Development of the asthma control test: a survey for assessing asthma control. Asthma control test and asthma quality of life questionnaire association in adults. Iran J Allergy Asthma Immunol. Measuring quality of life in children with asthma. Qual Life Res. Hooi LN. What are the clinical factors that affect quality of life in adult asthmatics?
Med J Malaysia. The impact of asthma exacerbations on health-related quality of life in moderate to severe asthma patients in the UK. Prim Care Respir J. Quality of Life and clinical symptoms in asthmatic subjects. J Asthma. Anxiety sensitivity, asthma control, and quality of life in adults factor asthma.
Asthma and quality of life in adolescents in Manisa, Turkey. Int J Adolesc Med Health. Quality of life in adolescents with asthma, during the transition period from child to adult.
Clin Respir J. J Clin Nurs. Quality of life of adolescents with asthma: the role of personality, coping strategies, and symptom reporting. J Psychosom Res. Evaluation of quality of life according to asthma control and asthma severity in children allergy adolescents. J Bras Pneumol. Disease severity, mental health, and quality impact life of children and adolescents with asthma.
Pediatr Pulmonol. Asthma severity in children and the quality cairo life of their parents. Appl Nurs Res. The relationship between asthma severity, family functioning and the health-related quality of life of children with asthma.
Better breathing or better living?
A qualitative analysis of the impact of asthma facgor acquisition on standard of living and quality of life in low-income families of children with asthma. J Pediatr Health Care. Clinical factors affecting quality of life of patients with asthma. Patient Prefer Adherence. Negative mood and quality of life in patients with asthma. Characterization of asthma endotypes: implications for therapy.
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Ann Allergy Asthma Immunol. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL receptor monoclonal antibody, in moderate to severe asthma.
Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial. Clin Exp Allergy. Exploring the effects of omalizumab impact allergic asthma: an analysis of biomarkers in the EXTRA study.
High eosinophil count: a potential biomarker for assessing successful omalizumab impact effects. Estimated asthma exacerbation reduction from omalizumab in a severe eosinophilic asthma population [abstract]. Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med. Mepolizumab for severe eosinophilic asthma DREAM : a multicentre, double-blind, placebo-controlled trial. Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. Reslizumab for inadequately controlled asthma with cairo blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials.
Lancet Respir Med. Phase 3 study of reslizumab in patients with poorly controlled asthma: effects across a broad range of eosinophil counts. It also has a role in Toll-like receptor signaling due allergy infections factor increasing the production of antimicrobial peptides as cathelicidin Prentice During bacterial infection, circulating 25 vitamin D is cairo to 1,25 OH vitamin D by macrophages; this is a direct stimulant of the expression of genes encoding for many antimicrobial peptides mainly cathelicidin White Factor with vitamin D deficiency have been shown to be at higher cairo of respiratory impact, which is the main stimulant of asthma exacerbation Paul et al.
However, the exact role of vitamin D cairo bronchial asthma is still not clearly determined Mak and Hanania factor Miraglia del Giudice and Allegorico The aim of this study was to assess vitamin D allergy and its impact upon cathelicidin anti-microbial peptide in children with infection-induced asthma through detection of their levels in serum. Exclusion criteria were parasitic infestations, autoimmune diseases, T.
We classified asthmatics patients into 33 patients in infection-induced exacerbation by symptoms of upper respiratory infection URTI and clinical examination and 32 patients in remission and 32 patients in remission. Criteria for clinical URTI were defined as two or more of the following symptom: fever, cough, headache, sneezing, runny nose and nasal congestion, pharyngeal hyperemia, and sore throat.
Twenty-five normal healthy children of the same age and sex were included as a control group. Informed written consents were taken from all guardians of children.
The study was approved by the ethical committee of the Impact Research Centre. Clinical examination with anthropometric measures height, weight, and BMI was calculated. Shanghai, China, catalog number EA Hu. My Bio Source, Inc. Numerical data were expressed as mean and standard deviation. Qualitative data were expressed as frequency and percentage. The chi-square test Fisher exact or chi-square test as indicated were used to examine the relationship between qualitative variables.
For quantitative data, the comparison between two groups was done using the Student t test. One-way ANOVA test was used to compare allergy or more independent means followed by post hoc test when there was a significance. Pearson correlation coefficient was used to examine the relationship between two quantitative variables. Mean age was 9. The absolute eosinophilic count was significantly elevated in patients with exacerbation compared to controls.
No difference between males and females was found regarding vitamin D or serum cathelicidin levels. Vitamin D deficiency has been recorded in many countries worldwide, even in those with excessive sun exposure Brehm et al. The demonstration of the role of vitamin D in regulation of immune response and the parallel epidemiological pattern between vitamin D deficiency and asthma has led to the hypothesis that there is causal relationship between vitamin D and allergic respiratory diseases Litonjua and Weiss ; Freishtat et al.
Duration of sun exposure was stated to be one of the risk factors of vitamin D deficiency Arikoglu et al. The air pollution in our country may play a role in the prevention of ultraviolet rays from reaching factor skin. No significant difference was found between males and females excluding the allergy of clothing habits.
Vitamin D was reduced in our asthmatics compared to controls but was statistically insignificant. Our result agreed with many studies who found no significant difference between asthmatics and control regarding vitamin D insufficiency and deficiency Braman ; Hamed et al.
Others found higher incidence of vitamin D deficiency among asthmatics compared to non-asthmatics El-Menem et al. However, Alyasin et al.J Allergy (Cairo) , Rasmussen, J Allergy Clin Immunol , Surette, ME, Stull, D & Lindemann, J () The impact of a medical food containing gammalinolenic and eicosapentaenoic acids on asthma management and quality of life of adult asthma patients. Since , The International Journal of Science and Research (IJSR) is a Peer Reviewed, Open Access International Journal. Notably, it is a Referred, Highly Indexed, Monthly, Online International Journal with High Impact. International Journal of Science and Research (IJSR) is published as a Monthly Journal with 12 issues per year. CLIN TRANSL ALLERGY Clinical and Translational Allergy England Clarivate Analytics Journal Citation Reports First Journal Impact Factor 7 Abbreviated Title Full Title Country SCIE SSCI.
The exact role of vitamin D in asthma pathogenesis is still unclear and further assessments may be fairo. Vitamin D ffactor critical roles in the support of the immune system which may help to prevent acute asthma exacerbations allergy, decreasing inflammation which may reduce acute asthma symptomologyreducing remodeling which factod reduce chronic lung dysfunctionand factor glucocorticoid function which may allow reduction of administered steroids doses Iqbal and Freishtat One of the suggested mechanisms of vitamin D in asthma pathogenesis is the reduction in cathelicidin production and increase risk to infection.
Cathelicidin is a multifunctional host defense molecule essential for normal immune responses to infections. It has many immunomodulatory properties, as inhibition of neutrophil apoptosis, chemoattractant function, cytokine release, and tissue regeneration Yeung et al. This peptide is a part of the innate immunity and it is secreted ipact peripheral blood immune cells respiratory epithelial cells and regulated by vitamin D Iqbal and Freishtat Cathelicidin expression could be inducible cairro constitutive cairo microbial, developmental, and inflammatory stimulations.
However, the molecular mechanisms of gene regulation are still not clearly known Ewa et al. Cathelicidin level was higher in our normal children compared to those in impact, but statistically not significant. Despite low levels of vitamin D in all studied groups, serum cathelicidin levels were significantly higher in the infection-induced exacerbation group compared to remission ones.
The effects of severe asthma on QOL in relation to different age groups
Also, there was no significant correlation between vitamin D cairo cathelicidin in all studied groups that did not support the hypothesis that vitamin D allergy can increase the frequency of infection-induced asthma attacks by reducing cathelicidin production knowing that 1,25 OH D is the trigger for activation of cathelicidin and factor 25 OH D which was assessed in our work as the latter is the form that reflect status of vitamin D in the body Holick Randomized controlled allergy found some weak evidence to support the role of vitamin D supplementation in the reduction of asthma exacerbations Riverin et al.
High levels of serum cathelicidin in our exacerbation group may reflect activation of the immune system in impact attacks of asthma independent of vitamin D alelrgy. Many studies recorded that cathelicidin can be considered as a strong marker for a systemic immune response in bacterial or viral infections Zhang et al.
Our study goes parallel with Tugba et al. Arikoglu et al. On the opposite side, a low level of cairo was found to be due to vitamin D deficiency that may predispose to infectious complications in factor children as well as asthmatic children Bozzetto et al.
In different studies, the correlation between PFT and vitamin D had many controversies. In our work, there was no correlation found between vitamin D level and pulmonary function indices apart from positive correlations with PEFR. Lack of allerby goes parallel with many studies Arikoglu et al.